The insignificance of MBL2 protein levels in conferring resistance to malaria infection in Uyo Metropolis, Akwa Ibom State, Nigeria
Keywords:
Mannose binding lectin, Malaria, Pattern recognition molecule, Immune systemAbstract
Mannose binding lectin (MBL2) is an innate immune system pattern recognition molecule that serves to identify pathogens through their surface antigen-pathogen associated molecular patterns and bind to particular sugar molecules on the surface of pathogens to activate their destruction by the immune system. The levels of the immune protein- mannose binding lectin- correlate with the resistance of an individual to disease infections. Samples for this study were recruited from the Uyo metropolis of Akwa Ibom State in Nigeria. The levels of MBL2 were measured by enzyme-linked immunosorbent assay in 60 malaria patients and 60 healthy individuals for determination of resistance or protection against malaria infection. MBL2 levels in malaria patients and healthy controls were 14.40ng/ml ± 13.04 and 19.90ng/ml ± 18.5 2, respectively. The results from the study showed that there was no association in MBL2 levels between malaria and controls (p=0.129) as well as between the different sub-groups. Therefore, levels of MBL2 are not a contributory factor in resistance against malaria in the population under study.
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